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Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2017;70:261-6 - Vol. 70 Num.04 DOI: 10.1016/j.rec.2016.11.018

High-sensitivity Troponin T Assay in Asymptomatic High Cardiovascular Risk Patients. The TUSARC Registry

Isabel Álvarez a, Luis Hernández b, Héctor García c, Vicente Villamandos d, María Gracia López e, Jorge Palazuelos Molinero f, Diego Martín Raymondi c,

a Medicina Familiar y Comunitaria, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
b Servicio de Medicina Interna, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
c Servicio de Cardiología, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
d Laboratorio de Análisis Clínicos, Hospital Santos Reyes, Aranda de Duero, Burgos, Spain
e Laboratorio de Análisis Clínicos, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain
f Servicio de Cardiología, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain

Keywords

High-sensitivity troponin T. High cardiovascular risk. Registry.

Abstract

Introduction and objectives

High-sensitivity troponin T assays (Hs-TnT) have been carried out in selected populations in clinical trials and in registries of the general population with low cardiovascular risk (CVR). The aim of this study was to determine the proportion of individuals with detectable Hs-TnT and the proportion of individuals with elevated Hs-TnT in a Spanish population of asymptomatic individuals with very high CVR, as well as the parameters associated with Hs-TnT elevation.

Methods

The study included 690 patients. Hs-TnT detection and Hs-TnT elevation (≥99th percentile value), as well the association of elevated Hs-TnT and clinical, analytical, and treatment data were analyzed.

Results

Hs-TnT was analyzed in 646 patients and was detected in 645. Elevated TnT was detected in 212 patients (32.9%). On multivariate analysis, elevated TnT was independently associated with male sex (OR, 2.81; 95%CI, 1.67-4.73; P < .001), older age (OR, 1.06; 95%CI, 1.04-1.09; P < .001), a higher body mass index (OR, 1.07; 95%CI, 1.02-1.12; P < .002), insulin therapy (OR, 1.99; 95%CI, 1.15-3.46; P = .01), history of heart failure (OR, 3.92; 95%CI, 1.24-12.39; P = .02), and estimated glomerular filtration rate calculated by CKD-EPI (OR, 0.96; 95%CI, 0.95-0.97; P < .001).

Conclusions

In a Spanish population of asymptomatic individuals at very high CVR, Hs-TnT was associated with older age, male sex, higher body mass index, insulin therapy, history of heart failure, and lower glomerular filtration rate.

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1885-5857/© 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved