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Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2018;71:344-50 - Vol. 71 Num.05 DOI: 10.1016/j.rec.2017.07.018

Coronary Flow Reserve and Ventricular Function Following Regenerative Treatment in Patients With Revascularized Acute Anterior Myocardial Infarction [Only available PDF version]

Flor Baeza Garzón a,, Manuel Pan Álvarez-Ossorio a, Miguel Ángel Romero Moreno a, Vanesa Martín Palanco b, Concepción Herrera Arroyo b, José Suárez de Lezo Cruz Conde a

a Servicio de Cardiología, Hospital Reina Sofía, Córdoba, España
b Servicio de Hematología, Hospital Reina Sofía, Córdoba, España


Bifurcations lesions. Coronary chronic total occlusion. Percutaneous coronary intervention.


Introduction and objectives

Bone marrow stem cells may reconstruct infarcted myocardium through distinct mechanisms. However, little is known on the relationship between recovery of muscular and microvascular function after regenerative treatments. Our objective was to analyze the relationship between changes in left ventricular and microvascular function in patients with anterior acute myocardial infarction receiving regenerative treatment.


We performed a pooled analysis of 2 clinical trials and a pilot study evaluating stem cell therapy in 88 patients with revascularized acute anterior myocardial infarction. Coronary flow reserve and left ventricular function were analyzed with identical methods in all patients. Patients treated with regenerative treatment received intracoronary bone¿marrow-derived mononuclear cell transplant (n = 40), subcutaneous administration of granulocyte colony-stimulating factor (n = 14), or a combination of both (n = 10). A control group of 24 patients was treated with conventional revascularization


Mean ejection fraction increased from 37% 8% to 46% ± 12%, (P < .05). Mean coronary flow reserve increased from 1.6 0.5 to 2.3 0.9 (P < .05). However, there was no correlation between parameters of left ventricular function and microvascular parameters at follow-up.


Left ventricular function shows favorable changes after regenerative treatment of infarction. However, no correlation was found between changes in microvascular and myocardial function after regenerative therapy.

1885-5857/© 2018 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved