ISSN: 1885-5857 Impact factor 2023 5.9
Vol. 71. Num. 3.
Pages 155-161 (March 2018)

Original article
Mortality and Atrial Fibrillation in the FIACA Study: Evidence of a Differential Effect According to Admission Diagnosis

Mortalidad y fibrilación auricular en el estudio FIACA: evidencia de un efecto diferencial según el diagnóstico al ingreso hospitalario

Francisco Guillermo Clavel-Ruipéreza1Luciano Consuegra-Sáncheza1Francisco Javier Félix RedondobLuis Lozano MerabcPedro Mellado-DelgadobJuan José Martínez-DíazaJosé Ramón López MínguezdDaniel Fernández-Bergésb
Rev Esp Cardiol. 2018;71:139-4010.1016/j.rec.2017.06.009
Claire Alexandra Lawson, Mamas Andreas Mamas

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Abstract
Introduction and objectives

Atrial fibrillation (AF) is an independent risk factor for mortality in several diseases. However, data published in acute decompensated heart failure (DHF) are contradictory. Our objective was to investigate the impact of AF on mortality in patients admitted to hospital for DHF compared with those admitted for other reasons.

Methods

This retrospective cohort study included all patients admitted to hospital within a 10-year period due to DHF, acute myocardial infarction (AMI), or ischemic stroke (IS), with a median follow-up of 6.2 years.

Results

We included 6613 patients (74 ± 11 years; 54.6% male); 2177 with AMI, 2208 with DHF, and 2228 with IS. Crude postdischarge mortality was higher in patients with AF hospitalized for AMI (incident rate ratio, 2.48; P < .001) and IS (incident rate ratio, 1.84; P < .001) than in those without AF. No differences were found in patients with DHF (incident rate ratio, 0.90; P = .12). In adjusted models, AF was not an independent predictor of in-hospital mortality by clinical diagnosis. However, AF emerged as an independent predictor of postdischarge mortality in patients with AMI (HR, 1.494; P = .001) and IS (HR, 1.426; P < .001), but not in patients admitted for DHF (HR, 0.964; P = .603).

Conclusions

AF was as an independent risk factor for postdischarge mortality in patients admitted to hospital for AMI and IS but not in those admitted for DHF.

Keywords

Atrial fibrillation
Prognosis
Heart failure
Acute myocardial infarction
Ischemic stroke

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