Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2006;59:50-6 - Vol. 59 Num.01 DOI: 10.1016/S1885-5857(06)60048-0

C-Reactive Protein and Interleukin-6 Serum Levels Increase as Chagas Disease Progresses Towards Cardiac Failure

Lyankis López a, Kaduo Arai a, Esther Giménez b, Mariela Jiménez a, Carmine Pascuzo b, Claudina Rodríguez-Bonfante c, Rafael Bonfante-Cabarcas b

a Asociación Cardiovascular Centro-Occidental (ASCARDIO), Escuela de Medicina, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Lara, Venezuela.
b Unidad de Bioquímica José Antonio Moreno Yánez, Escuela de Medicina, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Lara, Venezuela.
c Unidad de Investigaciones en Parasitología Médica, Escuela de Medicina, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Lara, Venezuela.

Keywords

Chagasic cardiomyopathy. C-reactive protein. Interleukin-6.

Abstract

Introduction and objectives. Chagas disease is the most common cause of myocarditis in Latin America, including Venezuela. Some 25% of patients progress to chronic chagasic cardiomyopathy, which is characterized by heart failure and arrhythmias. The serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) have prognostic value in non-chagasic cardiopathy. The goal of this study was to investigate the relationship between the serum levels of CRP and IL-6 and the developmental stage of Chagas disease. Patients and method. The study included 64 Chagas disease patients (34 female and 30 male; age 62.2 [1.7] years) and 20 healthy individuals (10 of each sex; age 50.4 [2.7] years). Clinical investigations included echocardiography and measurement of CRP and IL-6 serum levels using ELISAs. Chagas disease patients were graded according to Carrasco et al 1994 classification. Patients with ischemic cardiopathy, liver disease, autoimmune disease, a systemic inflammatory condition, immunosuppression, cancer, pericarditis, or endocarditis were excluded. Results. Multiple regression analysis demonstrated an association between Chagas disease developmental stage and the serum IL-6 level. The serum CRP level increased during only the most advanced phase of the disease. In addition, a high left ventricular mass index was associated with a high IL-6 level and male sex. Conclusions. IL-6 and CRP serum levels could be of prognostic value in assessing Chagas disease progression because there are significant correlations between elevated levels and the deterioration of cardiac function.

1885-5857/© 2006 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved

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