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Revista Española de Cardiología (English Edition) Revista Española de Cardiología (English Edition)
Rev Esp Cardiol. 2017;70:754-62 - Vol. 70 Num.09 DOI: 10.1016/j.rec.2017.02.046

The Genetics of Ischemic Heart Disease: From Current Knowledge to Clinical Implications

Roberto Elosua a,b,, Sergi Sayols-Baixeras a,b,c

a Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain
b Grupo de Epidemiología y Genética Cardiovascular, Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, Spain
c Departamento de Ciencias de la Salud y de la Vida, Universidad Pompeu Fabra, Barcelona, Spain

Refers to

The State of Cardiovascular Genomics: Abundant Data, Limited Information
Stella Aslibekyan, Edward A. Ruiz-Narváez
Rev Esp Cardiol. 2017;70:696-8
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Ischemic heart disease. Genetics. Pharmacogenomics. Cardiovascular risk.


Ischemic heart disease continues to cause high morbidity and mortality. Its prevalence is expected to increase due to population aging, and its prevention is a major goal of health policies. The risk of developing ischemic heart disease is related to a complex interplay between genetic, environmental, and lifestyle factors. In the last decade, considerable progress has been made in knowledge of the genetic architecture of this disease. This narrative review provides an overview of current knowledge of the genetics of ischemic heart disease and of its translation to clinical practice: identification of new therapeutic targets, assessment of the causal relationship between biomarkers and disease, improved risk prediction, and identification of responders and nonresponders to specific drugs (pharmacogenomics).


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1885-5857/© 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved